Description：

Rotavirus, member of Reoviridae family, is a non-enveloped double-stranded RNA (dsRNA) virus whose architecture is that three concentric capsids surround a genome of 11 segments of dsRNA. The RNA encodes six structural proteins (VP1, VP2, VP3, VP4, VP6 and VP7) and six non-structural proteins (NSP1, NSP2, NSP3, NSP4, NSP5 and NSP6), both determining the host specificity, cell entry and enzymatic functions and comprising epitopes that generate immune responses. The non-structural proteins are associated with genome replication. Two rotavirus vaccines are broadly used worldwide: the RV5 vaccine and the RV1 vaccine. RV5 vaccine is a live attenuated pentavalent vaccine,while the RV1 vaccine is a live attenuated human monovalent virus vaccine.

图1 轮状病毒结构示意图

图2 轮状病毒复制周期

参考文献：

[1] Crawford SE, et al. 2017. Nat Rev Dis Primers. 3:17083.

[2] Mahmud-Al-Rafat A, et al. 2018. Infection. 46(1):15-24.