Description：

Marburg virus, the first filovirus to be identified, constitutes the filovirus family together with five ebolavirus, causing highly lethal hemorrhagic fever. Marburg virus express a single protein on their envelope surface, a glycoprotein termed GP, which is responsible for attachment to, and entry of, host cells. GP forms a trimer on the viral surface. In the trimer, each monomer is comprised of GP1 and GP2 subunits that are anchored together by a GP1-GP2 disulfide bond. GP1 contains a receptor-binding core topped by a glycan cap and a heavily glycosylated mucin-like domain, while GP2 contains two heptad repeats and a transmembrane domain. Although the overall organization is similar between Marburg and Ebola GPs, several differences in sequence, glycosylation, mobility and conformation exist regarding GP1 and GP2.

图 马尔堡病毒GP的结构

参考文献：

[1] Hashiguchi T, et al. 2015. Cell. 160(5):904-912.

[2] Koellhoffer JF, et al. 2012. Biochemistry. 51(39):7665-75.