Hiscan VM Pro是一款快速灵活的活体显微CT，主要用于动物实验。其所用的锥束X射线可以看到样本的内部结构，最高分辨率可达18μm。可做小动物全身扫描，如小鼠、大鼠等。同时，可以扫描所选择的感兴趣区域，例如小鼠和大鼠的头部、脊椎、前肢 、后肢等。根据样本尺寸不同配以不同尺寸的扫描床，独特设计的扫描床可以防止小动物逃逸落进机器内。

　　Hiscan VM Pro配有高精度自适应呼吸门控，可根据呼吸周期的变化动态调整图像采集速度，有效减少呼吸带来的胸廓运动伪影。防护机壳配有麻醉气体传输接口以及多种生理监控设备接口。X射线机壳防护安全可靠，操作人员无需额外防护。同时配有安全连锁装置，仓门打开时自动关闭X射线，避免误操作，保证操作人员安全。

       广泛应用于骨骼疾病、肿瘤疾病、心血管疾病、炎症疾病、代谢疾病、免疫学、药效评价、生物材料等学科的临床前研究。

 

　► 高精度呼吸门控

　　通过高精度呼吸门控采集呼吸信号，根据呼吸信号波形进行图像采集获得同一呼吸相位的图像，从而消除呼吸运动带来的伪影，获得清晰的重建图像。同时具有自适应性，根据不同小鼠的呼吸频率自动调整图像采集速度，智能扫描。

　► 精密设计扫描床

　　经过精密设计的扫描床，操作方便，小动物放置在前部透明扫描仓内，配有摄像头监控小动物呼吸;同时配有麻醉气体接口，保证小鼠呼吸稳定;另外还配有造影剂持续注射接口，可持续造影，用于灌注成像。

   ► 多模态图像融合技术

　　为多模态图像融合设计独特配准装置，扫描床上有特定标记位点，在多种设备上均可成像，根据这些特定标记位点进行图像配准融合。

　► GPU加速快速分层重建

　　采用经过优化的快速分层重建算法，并使用GPU进行硬件加速，重建速度提高到扫描结束重建同时完成。

 

　

 

 

 

 

 

 

 

 

 

　　1、X光光源

　　★1.1光源焦点尺寸：最小5µm

　　1.2最大电压：90kV, 电压范围连续可调

　　1.3功率：8W

　　2、 X光探测器

　　2.1 X光探测器类型：平板探测器

　　2.2 X光探测器像素：1944*1536

　　★2.3探测器帧率：最快可达86fps

　　3、空间分辨率

　　3.1像素大小：最高18µm。

　　3.2 实际空间分辨率：30µm(10%MTF)。

　　4、扫描仓

　　4.1扫描床直径：≤80mm。

　　4.2扫描床长度：≤260mm。

　　4.3扫描仓内部孔径：≤100mm。

　　4.4 扫描床套装：配备小鼠、大鼠扫描床。

　　4.5 具备气体麻醉接口。

　　4.6 具备液体自动注射装置接口。

　　4.7 具备呼吸门控。

　　5、断层重建

　　5.1重建方式：GPU加速重建，实时重建，扫描的同时同步进行重建，扫描结束后即可查看重建结果。

　　5.2重建最大像素数量： 4Kx4K像素

　　5.3重建速度：≤15秒(512x512x100)

　　6、辐射防护，辐射自屏蔽机架：仪器表面X射线辐射剂量率<0.25µSv/h

　　7 、配套图像获取及软件分析系统

　　7.1扫描控制软件

　　7.2 数据重建软件

　　7.3 2D图片处理和分析软件

　　7.4重建结果可视化软件

　　7.5图片格式转换软件和DICOM 格式转换功能

　　8、电脑工作站

　　8.1系统：Windows 7或以上;

　　8.2处理器：3.4 GHz或以上

　　8.3内存：16GB DDR3或以上

　　8.4显卡：8GB独立显卡或以上

　　8.5硬盘：2TB SATA或以上

　　8.6显示器：24' LCD或以上

　　8.7 DVD+/- RW驱动

　　8.8 QWERTY键盘

　　8.9光学鼠标

 

参考文献：

1、Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization. Yingqian Wang, Jie Wang, Yufeng Zhang, Quan Yuan et al. Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University. Nature Communications. 2019,10,2829

2、GSH-Depleted PtCu3 Nanocages for Chemodynamic- Enhanced Sonodynamic Cancer Therapy. Xiaoyan Zhong, Liang Cheng, Yong’an Tang, Zhuang Liu, Xiangliang Yang, et al. National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology. Institute of Functional Nano and Soft Materials (FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University. Advanced Functional Materials, DOI: 10.1002/adfm.201907954.

3、CT/Bioluminescence Dual-Modal Imaging Tracking of Mesenchymal Stem Cells in Pulmonary Fibrosis. Hongying Bao, Jie Huang, Zhijun Zhang et al. CAS Key Laboratory of Nano-BioInterface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences. Small. DOI:10.1002/smll.201904314

4、Long-term in vivo CT tracking of mesenchymal stem cells labeled with Au@BSA@PLL nanotracers. Xinyu Ning, Jie Huang, Zhijun Zhang et al. CAS Key Laboratory of Nano-BioInterface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences. Nanoscale. DOI:10.1039/c9nr5637h

5、 Discovery of a natural small-molecule compound that suppresses tumor EMT, stemness and metastasis by inhibiting TGFβ /BMP signaling in triple-negative breast cancer. Lei Di, Li-Juan Liu, Rong Fu, Yong-Xian Cheng, Zhao-Qiu Wu, et al. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center. Journal of Experimental & Cancer Research. 2019,38,134

6、PEGylated hollow gold nanoparticles for combined X-ray radiation and photothermal therapy in vitro and enhanced CT imaging in vivo. Ru Wang, Yan Shen, et al. Department of Pharmaceutics, China Pharmaceutical University. School of Ophthalmology&Optometry, EyeHospital, School of Biomedical Engineering, Wenzhou Medical University. Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences. Department of Chemical Engineering Northeastern University, Boston. Department of Radiology, The First Affiliated Hospita lof Nanjing Medical University. Nanomedicine: Nanothechnology, Biology, and Medicine . 2019,16,195-205

7、Transplanted Endothelial Progenitor Cells Improve Ischemia Muscle Regeneration in Mice by Diffusion Tensor MR Imaging. Xin-Gui Peng, Shenghong Ju, Judy R. James, et al. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, southeast University. Department of Radiology, University of Mississippi Medical Center. Stem Cells International 2016, 3641401

8、The Role of Metal Nanoparticles in Influencing Arbuscular Mycorrhizal Fungi Effectson Plant Growth. Youzhi Feng, Shiying He, Ge Dong, Xiangui Lin et al. State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences. Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences. School of Biological Science and Medical Engineering, Southeast University. Environ. Sci. Technol. 2013, 47, 9496-9504

9、Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model. Cuiping Yang, Jun Dou, Ning Gu, et al. Department of Pathogenic Biology and Immunology, School of Medicine & Collaborative Innovation Center of Suzhou NanoScience and Technology, Southeast University. School of Biological Science & Medical Engineering & Collaborative Innovation Center of Suzhou NanoScience and Technology, Southeast University. ONCOTARGET . 2015,6(29),27714-27724

10、CT/fluorescence dual-modal nanoemulsion platform for investigating atherosclerotic plaques. Jiali Ding, Ning Gu, Ge Dong,Yu Zhang, et al. State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices. School of Biological Science and Medical Engineering, Southeast University. Department of Radiation, The First Affiliated Hospital of Nanjing Medical University. Department of Cardiology, Xuzhou Medical College Second Affiliated Hospital. Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Medical School, SoutheastUniversity. BIOMATERIALS. 2013,34(1), 209-216

11、Anti-ABCG2 monoclonal antibody in combination with paclitaxel nanoparticles against cancer stem-like cell activity in multiple myeloma. Cuiping Yang, Jun Dou, et al. Department of Pathogenic Biology and Immunology Medical School, Southeast University . NANOMEDICINE. 2014,9(1), 45-60

12、Single-Irradiation Simultaneous Dual-Modal Bioimaging Using Nanostructure Scintillators as Single Contrast Agent. Qiang Ju, et al. Advanced Healthcare Materials. 2019, 1801324

13、A novel calibration method incorporating nonlinear optimization and ball‐bearing markers for cone-beam CT with a parameterized trajectory. Guang Li, Shouhua Luo, Ge Wang, Ning Gu, et al. Department of Biomedical Engineering, Southeast University. Department of Biomedical Engineering, Rensselaer Polytechnic Institute.Department of Bioengineering and Electrical Engineering, StanfordUniversity. Med Phys. 2019, 46(1):152-164.

14、Interior tomography in microscopic CT with image reconstruction constrained by full field of view scan at low spatial resolution. Shouhua Luo ,Tao Shen, Guang Li, Xiangyang Tang, et al. Department of Biomedical Engineering, Southeast University. Department of Radiology and Imaging Sciences, Emory University School of Medicine. Physics in Medicine & Biology, 2018, 63(7).

15、Geometric Calibration Based on a Simple Phantom for Multi-Lens Microscopic CT. Shouhua Luo, Haitao Xu, Liang Zheng， Guang Li， et al. Department of Biomedical Engineering, Southeast University. International Journal of Computational Methods, 2018, 1842015.

16、An Epipolar Based Algorithm for Respiratory Signal Extraction of Small Animal CT. Shuang Luo, Shouhua Luo. Department of Biomedical Engineering, Southeast University. Sensing & Imaging, 2018, 19(1):4

17、A fast beam hardening correction method incorporated in a filtered back-projection based MAP algorithm. Shouhua Luo, Huazhen Wu, Guang Li, Ning Gu, et al. Southeast University. Phys. Med. Biol. 2017,62, 1810–1830

18、Automated image registration for stand-alone micro-PET and micro-CT. Jing Yang, Guang Li, Shouhua Luo, et al. School of Biological Science and Medical Engineering, Southeast University. Journal of Nanoscience and Nanotechnology, 2016,16 (7), 6903-6909

19、A method of extending the depth of focus of the high-resolution X-ray imaging system employing optical lens and scintillator: a phantom study. Guang Li, Shouhua Luo, Yulin Yan, Ning Gu. School of Biological Science and Medical Engineering, Southeast University. BioMedical Engineering OnLine, 2015,14(1)

20、Light field rendering of scintillator for X-ray imaging. Xiaolong Wang, Shouhua Luo, Guang Li, Jing Yang. School of Biological Science and Medical Engineering, Southeast University Acta Photonica Sinica. 2013, 42(12),1528-1533

 

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南京鼓楼医院 医学影像科

华东师范大学 生命科学学院

江苏省生物材料与器件重点实验室

东南大学 生物科学与医学工程学院

江苏省原子医学研究所 影像实验室

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