Recombinant Treponema pallidum (strain Nichols) 15 kDa Lipoprotein is produced by our E.coli expression system and the target gene encoding Cys18-Arg141 is expressed with a 6His tag at the N-terminus.

15 kDa lipoprotein; tpp15; TP15

16.3kDa

12-16kDa, reducing conditions

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10mM B-mercaptoethanol, 8M Urea, pH 8.0

N.A.

Reconstituted protein solution should be stored at ≤ -20°C.
Stable for at least 24 months when stored as instructed.

The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.

The antigenicity of the 15-kDa lipoprotein (Tpp15 or TpN15) of Treponema pallidum is modified with lipids.The native and the recombinant 15kD immunogens are amphiphilic proteins that appear to be located within the cytoplasmic membranes of their respective organisms. The lipoprolein structure of this potent immunogen is particularly significant in view of findings that the prototype bacterial lipoprotein, the murein lipoprotein of E.coli, and lipopeptides derived from its N-terminus, have unique B- and T-cell immunostimulatory properties. The Lipoprotein nature of the 15kD immunogen may have a direct bearing on the role of this molecule in syphilis immunopathogenesis.