中文名：

SMILES:NCCC1=CN(S(=O)(C2=C(Cl)N=C3SC=CN32)=O)C4=C1C=CC=C4

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Purity：98.05%

存储条件:Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.

产品详情: WAY-181187产品活性：WAY-181187 (SAX-187) 是一种有效的选择性 5-HT6 受体激动剂，Ki 为 2.2 nM，EC50 为 6.6 nM。WAY181187 介导 5-HT6 受体依赖性信号通路，如 cAMP，Fyn 和 ERK1/2 激酶，作为特异性激动剂。产品来源： 研究领域：GPCR/G Protein | Neuronal Signaling作用靶点：作用靶点：5-HT ReceptorIn Vitro: WAY181187 (1 and 10 μM) increases activation of ERK1/2. WAY181187 also increases Fyn kinase activity.In Vivo: Acute administration of WAY-181187 (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels.相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Kinase Inhibitor Library | Neuronal Signaling Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Obesity Compound Library | Targeted Diversity Library | Chlorpromazine hydrochloride | Serotonin hydrochloride | Puerarin | Harmine | SCH-23390 hydrochloride | GTS-21 dihydrochloride | Dihydroergotamine mesylate | SB-269970 hydrochloride | Brexpiprazole | Risperidone | Buspirone hydrochloride | Thioridazine hydrochloride | WAY-100635 Maleate | Aripiprazole | Ketanserin | Amitriptyline hydrochloride | 8-OH-DPAT | Cisapride | Trazodone hydrochloride | Quetiapine | Pimavanserin | Lurasidone | Vortioxetine hydrobromide | Pindolol | SB-224289 hydrochloride | SB 242084 | Volinanserin | Perphenazine | Methiothepin mesylate品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。

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