髓鞘少树突胶质细胞糖蛋白封闭多肽
MOG 35-55 (Guinea pig) active peptide
- bs-0426P
- 北京博奥森
- 北京市
- 现货
- 1mg
- 5mg
- 10mg
- 议价
- 2023-10-08 17:14:48
北京博奥森生物技术有限公司
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- 英文名称
- MOG 35-55 (Guinea pig) active peptide
产品编号
bs-0426P
产品分类
合成多肽
英文名称
MOG 35-55 (Guinea pig) active peptide
中文名称
髓鞘少树突胶质细胞糖蛋白封闭多肽
英文别名
MOG(35-55); myelin oligo-dendrocyte glycoprotein-MOG; MGC26137; MOG alpha 6; MOG; MOGIG2; Myelin oligodendrocyte glycoprotein; MOG_HUMAN.
蛋白细胞定位
细胞膜
纯化方法
HPLC
GeneID
4340
Swiss
Q61885
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Subunit
Homodimer. May form heterodimers between the different isoforms.
Subcellular Location
Cell membrane; Multi-pass membrane protein (Potential).
Tissue Specificity
Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
DISEASE
Defects in MOG are the cause of narcolepsy type 7 (NRCLP7) [MIM:614250]. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
Similarity
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Database links
Entrez Gene: 4340 Human
Entrez Gene: 17441 Mouse
Omim: 159465 Human
SwissProt: Q16653 Human
SwissProt: Q61885 Mouse
Unigene: 141308 Human
Unigene: 210857 Mouse
Unigene: 9687 Rat
背景资料
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
多肽活性
Yes
蛋白质与多肽-多肽序列
MEVGWYRSPFSRVVHLYRNGK (Guinea pig)
