小鼠抗表皮生长因子样激素受体1（EMR1）单克隆抗体
ADGRE1 (F4/80) Mouse mAb
- bsm-34028M
- 北京博奥森
- 北京市
- 现货
- 50ul
- 100ul
- 200ul
- 议价
- 2023-10-16 15:48:03
北京博奥森生物技术有限公司
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- 英文名称
- ADGRE1 (F4/80) Mouse mAb
概述
产品编号
bsm-34028M
产品分类
一抗
英文名称
ADGRE1 (F4/80) Mouse mAb
中文名称
小鼠抗表皮生长因子样激素受体1（EMR1）单克隆抗体
英文别名
F4/80 (mouse); Adhesion G protein-coupled receptor E1; Cell surface glycoprotein EMR1; Cell surface glycoprotein F4/80; DD7A5 7; Egf like module containing mucin like hormone receptor like 1; Egf like module containing mucin like hormone receptor like sequence 1; EGF like module receptor 1; EGF TM7; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EGFTM7; EMR 1; EMR1; EMR-1; EMR1 hormone receptor; EMR1_HUMAN; AGRE1_HUMAN; Gpf480; Ly71; Lymphocyte antigen 71; TM7LN3.
交叉反应
Human（predicted：Mouse,Rat）
抗体来源
Mouse
免疫原
KLH conjugated synthetic peptide derived from mouse F4/80
亚型
IgG
纯化方法
affinity purified by Protein G
克隆类型
Monoclonal
理论分子量
95kDa
检测分子量
160 kDa
浓度
200ug/ml
储存液
0.01M PBS(pH7.4) with 0.1% BSA, 0.03% Proclin300.
保存条件
Shipped at 4℃. Store at 2-8℃ for one year. Avoid repeated freeze/thaw cycles.
功能
Could be involved in cell-cell interactions.
亚基
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 6 EGF-like domains. Contains 1 GPS domain.
亚细胞定位
Cell membrane.
组织特异性
Wide expression; increased levels in peripheral blood mononuclear cells.
相似性
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 6 EGF-like domains.
Contains 1 GPS domain.
Contains 6 EGF-like domains.
Contains 1 GPS domain.
数据库链接
Entrez Gene: 2015 Human
Entrez Gene: 13733 Mouse
Omim: 600493 Human
SwissProt: Q14246 Human
SwissProt: Q61549 Mouse
Unigene: 2375 Human
Unigene: 2254 Mouse
背景资料
The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (1–3). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (1–3). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.
应用
| 应用 | 推荐稀释比例 |
|---|---|
| IF | 1:50-500 |
| IHC-P | 1:100-500 |
| WB | 1:100-1000 |
