信号通路Wnt5a抗体
WNT5A Rabbit pAb
- bs-1948R
- 北京博奥森
- 北京市
- 现货
- 按需
- 议价
- 2023-10-19 14:43:05
北京博奥森生物技术有限公司
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- 英文名称
- WNT5A Rabbit pAb
- 别名
- wingless-related MMTV integration site 5A; hWNT 5A; hWNT5A; Protein Wnt 5a; Protein Wnt5a; Wingless type MMTV integration site family member 5A; Wnt-5a; WNT 5A protein precursor; WNT5A protein precursor; WNT5A_HUMAN.
产品编号
bs-1948R
产品分类
一抗
产品类型
质检1级
英文名称
WNT5A Rabbit pAb
中文名称
信号通路Wnt5a抗体
英文别名
wingless-related MMTV integration site 5A; hWNT 5A; hWNT5A; Protein Wnt 5a; Protein Wnt5a; Wingless type MMTV integration site family member 5A; Wnt-5a; WNT 5A protein precursor; WNT5A protein precursor; WNT5A_HUMAN.
产品应用
WB, IHC-P, IHC-F, IF, Flow-Cyt, ELISA
交叉反应
Human,Mouse,Rat（predicted：Pig,Cow,Rabbit）
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human WNT5A:301-381/381
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
35kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
功能
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
亚基
Interacts with PORCN. Interacts with WLS.
亚细胞定位
Secreted, extracellular space, extracellular matrix.
组织特异性
Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
翻译后修饰
Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding. Glycosylation is necessary for secretion but not for activity.
疾病
Defects in WNT5A are the cause of Robinow syndrome autosomal dominant (DRS) [MIM:180700]. A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.
相似性
Belongs to the Wnt family.
数据库链接
Entrez Gene: 7474 Human
Entrez Gene: 22418 Mouse
Omim: 164975 Human
SwissProt: P41221 Human
SwissProt: P22725 Mouse
Unigene: 643085 Human
Unigene: 287544 Mouse
Unigene: 48749 Rat
背景资料
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
