Toll样受体7抗体
TLR7 Rabbit pAb
- bs-6601R
- 北京博奥森
- 北京市
- 现货
- 按需
- 议价
- 2023-10-18 14:08:08
北京博奥森生物技术有限公司
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- 英文名称
- TLR7 Rabbit pAb
- 别名
- TLR-7; PRO285; TLR 7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248.
产品编号
bs-6601R
产品分类
一抗
产品类型
质检1级
英文名称
TLR7 Rabbit pAb
中文名称
Toll样受体7抗体
英文别名
TLR-7; PRO285; TLR 7; TLR7_HUMAN; Toll like receptor 7; Toll-like receptor 7; UNQ248.
交叉反应
Human
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human TLR7
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
121kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
功能
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
亚基
Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1.
亚细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
组织特异性
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
相似性
Belongs to the Toll-like receptor family.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
数据库链接
Entrez Gene: 51284 Human
Entrez Gene: 170743 Mouse
Omim: 300365 Human
SwissProt: Q9NYK1 Human
SwissProt: P58681 Mouse
Unigene: 101913 Cow
Unigene: 659215 Human
Unigene: 23979 Mouse
背景资料
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
