高质量羊驼PBMC，纳博生命出品
1989 年，Hamers-Casterman 等偶然发现骆驼(单峰驼)血液中有半数的抗体是重链抗体(HCAbs)，它是一种缺失了轻链的重链二聚体抗体。HCAbs 普遍存在于单峰驼、亚州双峰驼、南美洲的大羊驼、原驼、羊驼等种类的偶蹄目骆驼科(Camelidae)动物血清中。
HCAbs可通过重链上的一个可变区识别抗原，这个可变区可以单独稳定的在体外存在，且具有完整的抗原结合能力，其分子量只有15kD左右，约为传统抗体的1/10，大小约2.4nm，被称为驼类单域抗体或纳米抗体。纳米抗体具有分子量小，高水溶性，高稳定性，较低的免疫原性，较高的组织穿透力以及易于人源化等诸多优点，相比于传统抗体，这一系列优势在抗体药物研发方面具有极大的潜力，故受到广大研究学者的重点关注。
In 1989, researchers discovered that camel blood contains a unique type of antibody called heavy chain antibodies (HCAbs). These antibodies, found in camels and other camelid species such as alpaca, lack light chains and are smaller in size compared to traditional antibodies.
HCAbs have a variable region on the heavy chain that allows them to recognize antigens independently. These antibodies, also known as nanobodies, have several advantages including their small size, high solubility, stability, low immunogenicity, and ability to penetrate tissues effectively. These qualities make nanobodies a promising tool in antibody drug development, attracting significant interest from researchers.
纳博生命为满足市场关于骆驼种属的研究，基于公司自身产品研发的基础和专业的研发技术人员，开发出高质量的羊驼外周血单个核细胞提取和纯化的方法。
实验原理主要是根据羊驼外周血中的单个核细胞的体积、形态和比重与其他细胞存在较大的差异，利用这些细胞密度的差异，通过密度梯度离心将外周血中的各种血细胞和单个核细胞分离开来。目前纳博成熟的羊驼PBMC分离技术，可以保证细胞在分离过程中活力不受损害，纯化过程单个核细胞纯度较好，可供研究学者后期进行细胞培养和抗体制备等其他研究。
NABO Life Science has developed a high-quality method for extracting and purifying peripheral blood mononuclear cells (PBMCs) from alpaca.
This method is based on the company's own research and development expertise and aims to meet the market demand for camel species research. By utilizing the differences in size, morphology, and density between PBMCs and other cells in alpaca blood, NABO is able to separate and purify PBMCs using density gradient centrifugation.
The developed technique ensures the preservation of cell viability and achieves good purity of individual nuclear cells. This provides researchers with reliable materials for various studies, including cell culture and antibody preparation.
纳博生命研发技术人员具备多年的PBMC分离经验，羊驼PBMC细胞活率高，纯度好，产品安全性高，实验羊驼均经过相关传染源检测，无传染源。
a)细胞活率高：纳博生命研发技术人员具备多年的PBMC分离经验，实验过程中所使用的分离试剂对细胞无毒无刺激，对细胞无伤害，最大程度上保证细胞的的原始状态，分离后的细胞或冻存复苏后的活率可达80%以上。
b)细胞纯度好：实验室独特的细胞纯化技术，尽可能的去除掉其他组分，保证PBMC的纯度，从而降低其他组分对实验的干扰。
c)产品安全性高：纳博生命拥有符合实验动物标准的羊驼繁育基地，严格把控羊驼质量，实验羊驼均经过相关传染源检测，无传染源，客户可放心的使用。
NABO Life Science's research and development team has extensive experience in isolating peripheral blood mononuclear cells (PBMCs), resulting in high cell viability and purity for alpaca PBMCs.
The experimental process utilizes separation reagents that are non-toxic and non-irritating to cells, ensuring minimal cell damage and preserving their original state. The cell viability after isolation or post-thaw recovery can reach over 80%.
The laboratory team unique cell purification techniques to remove other components and maintain the purity of PBMCs, minimizing interference from other substances in experiments. NABO Life Science prioritizes product safety by maintaining a alpaca breeding base that complies with laboratory animal standards.
The experimental alpacas undergo testing for infectious sources, ensuring that they are free from contagious agents. Customers can confidently use our products.
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