种属：Human;Mouse
应用：WB;ELISA
Fields：>>Axon guidance
基因名称（Gene Name）：SEMA6D KIAA1479
蛋白名称：Semaphorin-6D
人基因ID：80031
人蛋白质序列数据库：Q8NFY4
小鼠蛋白质序列数据库：Q76KF0
大鼠基因ID：nan
大鼠蛋白质序列数据库：nan
免疫原：Synthesized peptide derived from part region of human protein
特异性：SEM6D Polyclonal Antibody detects endogenous levels of protein.
组成（Formulation）：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
来源：Polyclonal, Rabbit,IgG
稀释比例：WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度：1 mg/ml
储存（Storage）：-20°C/1 year
其他名称：nan
分子量（DA）：118kD
背景（Background）： Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010],
功能：caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.,similarity:Belongs to the semaphorin family.,similarity:Contains 1 PSI domain.,similarity:Contains 1 Sema domain.,
细胞定位：[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; [Isoform 7]: Cytoplasm.
组织表达： Brain,Whole embryo,