微管蛋白β tubulin/Tubulin β（内参）抗体
Beta tubulin (Loading Control) Rabbit pAb
- bs-4511R
- 北京博奥森
- 北京市
- 现货
- 按需
- 议价
- 2023-10-18 13:55:24
北京博奥森生物技术有限公司
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- 英文名称
- Beta tubulin (Loading Control) Rabbit pAb
- 别名
- Beta 4 tubulin; Tubulin-beta; Tubulin beta; Beta 5 tubulin; BetaTubulin; Beta-Tubulin; dJ40E16.7; TUBB; TUBB2; TUBB2A; TUBB5; tubulin beta 2A; Tubulin beta chain; Tubulin beta-5 chain; TUBB4A; TUBB4; Tubulin 5 beta; Tubulin beta-4 chain; TBB4A_HUMAN; Tubulin beta-4A chain.
产品编号
bs-4511R
产品分类
一抗
产品类型
内参抗体、质检1级
英文名称
Beta tubulin (Loading Control) Rabbit pAb
中文名称
微管蛋白β tubulin/Tubulin β（内参）抗体
英文别名
Beta 4 tubulin; Tubulin-beta; Tubulin beta; Beta 5 tubulin; BetaTubulin; Beta-Tubulin; dJ40E16.7; TUBB; TUBB2; TUBB2A; TUBB5; tubulin beta 2A; Tubulin beta chain; Tubulin beta-5 chain; TUBB4A; TUBB4; Tubulin 5 beta; Tubulin beta-4 chain; TBB4A_HUMAN; Tubulin beta-4A chain.
交叉反应
Rat,Mouse,Human（predicted：Rabbit）
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human tubulin Beta
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
50kDa
浓度
1mg/ml
储存液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
功能
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
亚基
Dimer of alpha and beta chains. May interact with RNABP10. Interacts with PIFO. Interacts with MX1.
亚细胞定位
Cytoplasmic, cytoskeleton.
组织特异性
Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
翻译后修饰
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
相似性
Belongs to the tubulin family.
数据库链接
Entrez Gene: 203068 Human
Entrez Gene: 22154 Mouse
Omim: 191130 Human
SwissProt: P07437 Human
SwissProt: P99024 Mouse
Unigene: 636480 Human
Unigene: 2458 Rat
背景资料
This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
